Your Cat's Poop Could One Day Treat Cancer
Researchers say a microscopic organism living in a cat's tube can be used one day as a cancer treatment.Toxoplasma is a single-celled parasite that lives in the intestines of cats, but can also infect animals and other humans. Although toxoplasmosis infection is common among people, very few
people have symptoms due to attacks of their immune system, and prevents
the parasite from causing the disease.
Now, researchers are trying to harness the immune response caused by parasites and direct tumor attackers. Although the toxoplasmosis parasite is not the only microbe studied in the field of hot immune cancer, researchers may have some unique abilities, the researchers said."We know that biologically, this parasite has discovered how to stimulate the immune response you want exactly to fight cancer," said David J. Bezek, professor of microbiology and immunology at the Dartmouth School of Medicine at Dartmouth College in New Hampshire. [10 most evil and disgusting parasites]Toxoplasma parasite using Bzik transgenic and fellow mice treated with melanoma skin cancer and mice with ovarian cancer. Recent studies have shown that treatment has decreased tumor and increased chances of rat survival.However, much work is needed before treatment based on cancer, toxoplasma can be left to the laboratory and to the clinic, the researchers said.Life of the parasite
The parasite of Toxoplasma everywhere - affects most types of animals with warm blood, and can be found anywhere in the world almost. "The parasite learned not to kill the host, not to allow the killing of the host, for example, a very inflammatory response," Bzik said. "To achieve this achievement, you have to be able to handle immune responses."When the parasite invades an animal's body, the immune response kills any rapid replication of the parasite cell and protects the host's death. (Later, when the acute infection is over, the parasite becomes a latent form that the host then brings to the tissues, muscles and brain for life).Specifically, the immune system of animals respond to toxoplasmic infection by releasing cells called CD8 + T cells - a type of cell that destroys cells infected with viruses and cancer cells. [11 facts about the sudden immune system]"It turns out that T cells are CD8 + really important in cancer," Bzik told Science Life Science. "They are the most important type of cell that can destroy cancer cells, but the tumor-generation is closed."To re-activate the antimicrobial immune response in mice with cancer, the researchers used a safer form of toxoplasmosis. To do this, the genome manipulates parasites that can not be repeated in animals or people and thus can not cause disease.It is a vaccine organism and injected into large tumors in mice. Bzik said parasite then entered cells that encapsulated CD8 + T cells and let them go to work, attacking cancer cells.So far, researchers have tried six times skin cancer tumors - although tumors have been highly developed, the size has been reduced to detectable after 12 days, and multiple treatments. Bzik survived about 90 percent of mice."In aggressive ovarian cancer, positive results are similar, but when ovarian cancer treatment is aggressive, there is a more aggressive model of ovarian cancer for mice and for long periods of survival, but all mice undergo elective tumors," Bzik said. However, researchers can keep long live mice from dealing with them every two weeks.Bzik and his colleague said that further research is needed to understand the exact mechanisms behind the immune response of parasitic triggers. They said in addition, before treatment can be tested in people, researchers do intensive tests to make sure they are safe.
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يونيو 17, 2017